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in 2006 the results of 30-day study were published indicating that orlistat at a dosage of 200 mg kg chow administered to rats consuming a high-fat chow and receiving two 25 mg kg doses of the potent carcinogen 1,2-dimethylhydrazine produced significantly higher numbers of aberrant crypt foci acf colon lesions than did the carcinogen plus high-fat chow without orlistat.